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Isolated lung perfusion for pulmonary metastases, a review and work in progress

Department of Pulmonary Medicine, St Antonius Hospital, Nieuwegein, The Netherlands

Jos Heeren

Department of Anesthesiology, St Antonius Hospital, Nieuwegein, The Netherlands

Bart P Van putte

Department of Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, The Netherlands

Jeroen MH Hendriks

Department of Thoracic and Vascular Surgery, University Hospital Antwerp, Edegem, Belgium

Wim J Van boven

Department of Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, The Netherlands

Paul EY Van schil

Department of Thoracic and Vascular Surgery, University Hospital Antwerp, Edegem, Belgium

Franz MNH Schramel

Department of Pulmonary Medicine, St Antonius Hospital, Nieuwegein, The Netherlands

Pulmonary metastasectomy is a widely accepted treatment for many patients with pulmonary metastases from various solid tumors. Nevertheless, 5–year survival is disappointing, with rates of 25–40%, and many patients develop recurrences. Isolated lung perfusion (ILuP) is a promising new technique to deliver high–dose chemotherapy to the lungs, while minimising systemic toxicities. This procedure is technically safe and feasible; however, clinical value and efficacy remain unclear. The aim of this paper is to give a review of literature on ILuP in humans, and to describe the development of the perfusion procedure in our institute.

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Perfusion, Vol. 21, No. 5, 267-276 (2006)
DOI: 10.1177/0267659106073984


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