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Delayed thrombin generation is not associated with fibrinopeptide formation during prolonged cardiopulmonary bypass with hirudin anticoagulation

Department of Cardiovascular Perfusion, University of Ottawa Heart Institute, Ottawa, Canada

F D Rubens

Department of Surgery, Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada

B Henley

A Babaev

Department of Cardiovascular Perfusion, University of Ottawa Heart Institute, Ottawa, Canada

T Mesana

Department of Surgery, Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada

Patients with heparin-induced thrombocytopenia urgently requiring surgery with cardiopulmonary bypass (CPB) present a unique management challenge that must be addressed by the use of alternative anticoagulants. Although clinical success with the direct thrombin inhibitor hirudin has been reported, there is sparse information in the literature supporting the efficacy of this drug as an anti-thrombotic to prevent fibrin formation during CPB. In this report, we describe the efficacy of this drug to prevent thrombin-mediated fibrin formation during CPB.

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Perfusion, Vol. 21, No. 5, 259-262 (2006)
DOI: 10.1177/0267659106074768


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Belway, D Articles by Mesana, T Search for Related Content PubMed PubMed Citation Articles by Belway, D Articles by Mesana, T Social Bookmarking                         What's this?