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Perfusion, Vol. 9, No. 2,
109-117 (1994)
DOI: 10.1177/026765919400900205
Roller and centrifugal pumps compared in vitro with regard to haemolysis, granulocyte and complement activation
Oddvar Moen
Department of Cardiothoracic Surgery and Institute for Experimental Medical Research, Ullevål Hospital
Erik Fosse
Department of Cardiothoracic Surgery, Ullevål Hospital
Jennifer Bråten
Department of Cardiothoracic Surgery, Ullevål Hospital
Conny Andersson
Department of Cardiothoracic Surgery, Ullevål Hospital
Magne K. Fagerhol
Blood Bank and Department of Immunology, Ullevål Hospital, Norway
Per Venge
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden
Kolbjørn Hegåsen
Institute of Immunology and Rheumatology, The National Hospital, University of Oslo
Tom Eirik Mollnes
Department of Immunology and Transfusion Medicine, Nordland Central Hospital, Bodø, Norway
A Biomedicus centrifugal pump and a Polystan roller pump were compared in vitro with regard to differences in haemolysis, granulocyte and complement activation. Six circuits of tubing and oxygenators were connected to each pump. Heparinized fresh human blood was circulated for 72 hours in the systems. Blood samples were drawn at defined intervals. Haemolysis was assessed by determination of lactate dehydrogenase (LD) and potassium, and granulocyte activation by quantification of the granulocyte proteins calprotectin, lactoferrin and myeloperoxidase. Complement activation was assessed by measuring C3 activation products (C3b, iC3b and C3c), and the terminal C5b-9 complement complex (TCC). The results indicate more haemolysis and complement activation in the roller pump group, revealed by significantly higher concentrations of LD, potassium, C3 activation products and TCC. Calprotectin, lactoferrin and myeloperoxidase were all significantly increased in both groups, but the rise appeared earlier in the roller pump group. The concentrations of LD and potassium both correlated significantly with C3 activation products, indicating that complement activation may at least partly be responsible for the haemolysis.
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