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Clinical evaluation of the LeukoGuard (LG-6) arterial line filter for routine open-heart surgery

Lehigh Valley Hospital, Allentown, Pennsylvania

Norman J Manley

Lehigh Valley Hospital, Allentown, Pennsylvania

Ralph M Montesano

Lehigh Valley Hospital, Allentown, Pennsylvania

Geary L Yeisley

Lehigh Valley Hospital, Allentown, Pennsylvania

David Gordon

Lehigh Valley Hospital, Allentown, Pennsylvania

Research has demonstrated that leucocyte depletion diminishes the deleterious effects that activated neutrophils have on the body following cardiopulmonary bypass (CPB). A clinical evaluation involving 36 patients (18 in each group) was conducted to compare the use of the Pall LG-6 (leucocyte-depleting) arterial line filter with the Pall EC PLUS filter for postoperative complications and lung function on routine open-heart cases. No differences were found between the groups for postoperative chest tube drainage, urine output, on bypass platelet drop, chest X-rays, blood usage and circulating elastase levels. Statistically significant differences were observed between immediately post-CPB pO ₂ values and ventilator hours (EC PLUS = 13.3, LG-6 = 9.2). Many of the advantages of using leucocyte depletion that have been illustrated through experimental investigations were comparable to our clinical observations. We conclude that using the LG-6 leucocyte-depleting arterial line filter is a cost-effective method to reduce the complications known as 'postperfusion' syndrome.

Perfusion, Vol. 8, No. 6, 489-496 (1993)
DOI: 10.1177/026765919300800608


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