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Leucocyte depleting filters and cardiothoracic surgery

S. Hart

Pall Biomedical, Portsmouth, Hampshire

JA Roe

Pall Biomedical, Portsmouth, Hampshire

Leucocyte filtration technology is now beginning to be used in cardiothoracic surgery. The leucocyte depletion of banked homologous blood has been shown to reduce its immunosuppressive effects, along with a range of other benefits. Use of such a blood product appears to be an attractive option during cardiopulmonary bypass (CPB) as this procedure is recognized as causing immune disturbance and long-term immunosuppression.

White-cell removal filters also appear to have a novel application in the reduction of neutrophil-mediated damage associated with CPB procedures. A strong database from animal work has been recently supplemented by human data that shows clinical benefits from autologous white-cell removal by filtration.

Perfusion, Vol. 8, No. 6, 477-482 (1993)
DOI: 10.1177/026765919300800606
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