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Perfusion
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Haemostatic dysfunction and cardiopulmonary bypass: mechanisms and therapeutic choices

Colin Prentice

Academic Unit of Medicine, Leeds General Infirmary and University of Leeds, Leeds

Margaret Orchard

Academic Unit of Medicine, Leeds General Infirmary and University of Leeds, Leeds

Colin Goodchild

Academic Unit of Medicine, Leeds General Infirmary and University of Leeds, Leeds

Cardiopulmonary bypass is characterized by multiple haemostatic defects. These are due to haemodilution, platelet damage, the effects of hypothermia, heparin administration, and, in many patients, preoperative use of aspirin. The result is often excessive blood loss. Pharmacological agents such as desmopressin, prostacyclin, and aprotinin have been introduced to improve haemostasis during cardiopulmonary bypass. The protease inhibitor aprotinin appears to be particularly promising in reduction of bleeding associated with bypass. Study of aprotinin may provide new insights into the mechanisms of haemostatic dysfunction, particularly platelet dysfunction.

Perfusion, Vol. 8, No. 1 suppl, 28-35 (1993)
DOI: 10.1177/026765919300800105
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?