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Perfusion
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In vitro evaluation of the Mera Silox-S 0.5 and 0.8 m2 silicone hollow-fibre membrane oxygenator for use in neonatal ECMO

K. Rais-Bahrami

Children's National Medical Center, Washington DC

G. Mikesell

Children's National Medical Center, Washington DC

WR Seale

Children's National Medical Center, Washington DC

O. Rivera

Children's National Medical Center, Washington DC

JP Hearty

Children's National Medical Center, Washington DC

BL Short

Children's National Medical Center, Washington DC

The Mera Silox-S is a silicone hollow-fibre membrane oxygenator made up of thousands of fibres in a clear polycarbonate housing. Being a silicone membrane it does not have the plasma leakage problem associated with conventional microporous hollow fibres when used in a long-term application. This device (Mera Senko Medical Instrument Co., Japan) is made in three sizes: 0.3, 0.5 and 0.8 m2. The performance of the 0.5 m2 and 0.8 m2 Silox-S membrane oxygenators was tested in vitro using filtered ovine blood and a customized test circuit designed to provide a continuous source of de-oxygenated, CO2-laden blood, according to the AAMI standard for oxygenator performance.

The 0.8 m2 membrane provided excellent oxygenation, with a transfer rate of 13.0-43.5 ml/min for blood flows of 200-800 ml/min. CO2 transfer over the same range of flows measured 32.3-40.8 ml/min. Flow rates of 100-500 ml/min for the 0.5 m2 membrane provided an oxygen transfer of 6.8-28.3 ml/min and would probably not be suited for the existing neonatal ECMO population. A matter of concern with both oxygenators was an increased pressure drop for blood flow through the devices. The {Delta}Pfor the 0.5 m2 for flows of 100-500 ml/min ranged from 155 ± 7 mmHg to 516 ± 6 mmHg. For the 0.8 m2, {Delta}P was 194 ± 39 mmHg to 492 ± 53 mmHg for flows of 200-800 ml/min. Overall, favourable results support further long-term evaluation for potential use in neonatal ECMO.

Perfusion, Vol. 7, No. 4, 315-320 (1992)
DOI: 10.1177/026765919200700411
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