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Aprotinin in aspirin-pretreated patients

Ben P Bidstrup

Humana Hospital Wellington, London

David Royston

Humana Hospital Wellington, London

Cathy McGuinness

Humana Hospital Wellington, London

Ralph N Sapsford

Humana Hospital Wellington, London

Forty-four patients who had been taking aspirin underwent aortocoronary bypass surgery; twenty-six selected randomly received high-dose aprotinin (total 700mg approximately). Chest drainage was reduced from 1393ml to 352ml. Haemoglobin loss was reduced fourfold and there was a marked reduction in blood and blood product use in the aprotinin-treated patients. In an era where the need to reduce blood usage is vital, we conclude that aprotinin is effective in reducing bleeding in aspirin-treated patients, known to be at greater risk of postoperative haemorrhage.

Perfusion, Vol. 5, No. 1 suppl, 77-81 (1990)
DOI: 10.1177/026765919000500112
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