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Perfusion
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Plasma levels of glucose, insulin and cortisol in children undergoing cardiac surgery: effects of pulsatile and nonpulsatile perfusion

W.T. Vigneswaran

Royal Hospital for Sick Children, Glasgow

J.C.S. Pollock

Royal Hospital for Sick Children, Glasgow

M.P.G. Jamieson

Royal Hospital for Sick Children, Glasgow

B. Torsney

Royal Hospital for Sick Children, Glasgow

G.H. Beastal

Royal Hospital for Sick Children, Glasgow

The effects of pulsatile and nonpulsatile perfusion on the plasma glucose, insulin and cortisol levels were studied in 12 children undergoing intracardiac repair of congenital heart defects. Hyperglycaemia was noted in both subgroups during the operation but plasma glucose returned to normal levels at 24 hours. Insulin secretion was suppressed during the period of extracorporeal circulation (ECC) and this was pronounced while the aorta was crossclamped. Cortisol levels were elevated during the whole period of study and remained elevated at 24 hours. In the pulsatile group cortisol levels were higher than the nonpulsatile group. However there was no significant difference between the groups.

Like adults, children exhibit a metabolic response during open-heart operations. Pulsatile perfusion delivered by a modified Stöckert roller pump during ECC, did not alter the glucose, insulin and cortisol response to cardiac surgery in this study.

Perfusion, Vol. 4, No. 1, 33-39 (1989)
DOI: 10.1177/026765918900400105
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