This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Marath, A. Articles by Taylor, K. Search for Related Content PubMed Articles by Marath, A. Articles by Taylor, K. Social Bookmarking                   What's this?

Paediatric extracorporeal priming procedures: does low temperature priming promote histamine release?

Hammersmith Hospital, London

W. Man

Hammersmith Hospital, London

KM Taylor

Hammersmith Hospital, London

We have recently reported pathologically elevated plasma histamine levels in adult patients undergoing cardiac surgery throughout the perioperative period. We have found markedly higher histamine levels in paediatric practice. The priming volume of the smallest extracorporeal systems is invariably greater than the circulating blood volume of neonates and infants, necessitating the use of stored donor blood in the initial priming procedure. In 40 paediatric cases, arbitrarily selected, sampling from the arterial port of the oxygenator prior to the initiation of bypass revealed massively elevated plasma histamine levels (>30ng/ml) in those extracorporeal circuits in which the priming volume was smallest and the priming temperature lowest - at 10-12°C. It is clear that the use of donor blood (in this series less than five days old) may contribute to the delivery of histamine into the paediatric patient's circulation at the onset of cardiopulmonary bypass and that the priming temperature may play a role.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				W. Man, A. Steger, S. Hosking, and K. Taylor Histamine release during cardiopulmonary bypass Perfusion, April 1, 1990; 5(2): 107 - 116. [Abstract] [PDF]