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Perfusion
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research-article

Bioline® heparin-coated ECMO with bivalirudin anticoagulation in a patient with acute heparin-induced thrombocytopenia: the immune reaction appeared to continue unabated

F Pappalardo

Department of Cardiovascular Anesthesia and Intensive Care, Vita-Salute University, IRCCS San Raffaele Hospital, Milan, Italypappalardo.federico{at}hsr.it

G Maj

Department of Cardiovascular Anesthesia and Intensive Care, Vita-Salute University, IRCCS San Raffaele Hospital, Milan, Italy

A Scandroglio

Department of Cardiovascular Anesthesia and Intensive Care, Vita-Salute University, IRCCS San Raffaele Hospital, Milan, Italy

F Sampietro

Coagulation Service and Thrombosis Research Unit, IRCCS San Raffaele Hospital, Milan, Italy

A Zangrillo

Department of Cardiovascular Anesthesia and Intensive Care, Vita-Salute University, IRCCS San Raffaele Hospital, Milan, Italy

A Koster

Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany

Heparin-induced thrombocytopenia (HIT) is a serious, antibody-mediated complication of heparin which significantly confers risks of thrombosis and devastating outcomes. Once diagnosed, it requires immediate cessation of heparin and therapy with an alternative anticoagulant. No data are available in the literature on the pathophysiology and clinical implications of performing prolonged extracorporeal membrane oxygenation with a heparin-coated system in a patient with acute HIT treated with bivalirudin.

Key Words: bivalirudin • ECMO • heparin-induced thrombocytopenia • outcome • thrombosis

Perfusion, Vol. 24, No. 2, 135-137 (2009)
DOI: 10.1177/0267659109106773
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