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Clinical impact and biomaterial evaluation of autologous platelet gel in cardiac surgery

University of Kirikkale, Turkey sgunaydin{at}isnet.net.tr

K McCusker

New York Medical College, New York, USA

T Sari

Bayindir Hospital, Turkey

MA Onur

Hacettepe University, Turkey

A Gurpinar

Hacettepe University, Turkey

H Sevim

Hacettepe University, Turkey

P Atasoy

University of Kirikkale, Turkey

C Yorgancioglu

Hacettepe University, Turkey

Y Zorlutuna

Bayindir Hospital, Turkey

We compared the clinical efficacy of autologous platelet gel (APG) and gelatine (CONT), including biomaterial evaluation. In a prospective, randomized, controlled trial, 64 patients undergoing complex coronary artery bypass graft (CABG) surgery and/or aortic surgery, in whom the surgeon was able to identify a bleeding site for which conventional means to stop bleeding were impractical or proved unsuccessful, were enrolled. Aortic punch biopsy from each patient was harvested in explant cell (EC) culture media. Hemostasis success for the "oozing" category was 89% in APG and 60% in CONT (p< 0.05). For the "heavy bleeding" category, the success rates were 92% in APG and 45% in CONT (p<0.01). Contact of gelatine inhibited EC proliferation and APG increased cell cycling and EC quantity. Phagocytic capacity (PC) was significantly higher in the APG group (p<0.001). APG was significantly better than CONT with respect to hemostatic success rate, effects on wound healing and increased resistance to infection (PC).

Key Words: extracorporeal circulation • platelet activation • platelet gel • platelet rich plasma • surgical hemostasis

Perfusion, Vol. 23, No. 3, 179-186 (2008)
DOI: 10.1177/0267659108097783


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