This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hoel, T. N. Articles by Svennevig, J. L. Search for Related Content PubMed PubMed Citation Articles by Hoel, T. N. Articles by Svennevig, J. L. Social Bookmarking                         What's this?

Off-pump cardiac surgery abolishes complement activation

Department of Thoracic and Cardiovascular Surgery, Norwegian University of Science and Technoloyg, Trondheim, Norway, tom.nilsen.hoel{at}rikshospitalet.no

Vibeke Videm

Department of Immunology and Transfusion Medicine, St. Olav University Hospital and Institute of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway

Tom E. Mollnes

Institute of Immunology, Rikshospitalet-Radiumhospitalet Medical Center, and University of Oslo, Norway

Kjell Saatvedt

Department of Thoracic and Cardiovascular Surgery, Norwegian University of Science and Technoloyg, Trondheim, Norway

Frank Brosstad

Research Institute for Internal Medicine, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway

Arnt E. Fiane

Department of Thoracic and Cardiovascular Surgery, Norwegian University of Science and Technoloyg, Trondheim, Norway

Erik Fosse

Interventional center, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway

Jan L. Svennevig

Department of Thoracic and Cardiovascular Surgery, Norwegian University of Science and Technoloyg, Trondheim, Norway

Background. This prospective randomized study compared the inflammatory response in patients undergoing elective on-pump and off-pump coronary artery bypass grafting. Patients and methods. Forty-four patients undergoing elective coronary artery bypass grafting were recruited with 22 patients randomized to on-pump heart surgery and 22 patients to off-pump coronary bypass surgery. Plasma levels of C3bc, the terminal SC5b-9 complement complex, myeloperoxidase, ß -thromboglobulin and prothrombin fragment F1 + 2 were measured before the operation, intraoperatively, at termination of the operation, and two hours post-operatively. Results. Complement was markedly activated in the on-pump group as indicated by a significant increase in C3bc and SC5b-9 (p < 0.001 for both), whereas no complement activation was seen in the off-pump group (p = 0.001 between the groups). In contrast, both groups showed significant activation of neutrophils, platelets and coagulation, as indicated by an early increase in myeloperoxidase and a post-operative increase in ß-thromboglobulin and F1 + 2, respectively. Notably, there were no inter-group differences with regard to neutrophil and platelet activation, whereas coagulation activation was more pronounced in the off-pump group (p < 0.01). Conclusions. Off-pump surgery completely eliminated the heart-lung machine-induced complement activation. Neutrophils and platelets were equally activated in both groups, whereas coagulation was enhanced post-operatively in the off-pump group. Perfusion (2007) 22, 251—256.

Perfusion, Vol. 22, No. 4, 251-256 (2007)
DOI: 10.1177/0267659107084142


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. L. Ford, I. M. Mains, E. J. Hilton, S. T. Reeves, R. E. Stroud, F. A. Crawford Jr, J. S. Ikonomidis, and F. G. Spinale Endothelin-A Receptor Inhibition After Cardiopulmonary Bypass: Cytokines and Receptor Activation Ann. Thorac. Surg., November 1, 2008; 86(5): 1576 - 1583. [Abstract] [Full Text] [PDF]

				A. Castellheim, T. N. Hoel, V. Videm, E. Fosse, A. Pharo, J. L. Svennevig, A. E. Fiane, and T. E. Mollnes Biomarker Profile in Off-Pump and On-Pump Coronary Artery Bypass Grafting Surgery in Low-Risk Patients Ann. Thorac. Surg., June 1, 2008; 85(6): 1994 - 2002. [Abstract] [Full Text] [PDF]

				K Svennevig, T. Hoel, A. Thiara, S. Kolset, A Castelheim, T. Mollnes, F Brosstad, E Fosse, and J. Svennevig Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass Perfusion, May 1, 2008; 23(3): 165 - 171. [Abstract] [PDF]