Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Perfusion
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Dunningham, H.
Right arrow Articles by Gordon, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dunningham, H.
Right arrow Articles by Gordon, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Modelling lung and tissue diffusion using a membrane oxygenator circuit

H. Dunningham

Cambridge Perfusion Services, Papworth Hospital, Papworth Everard, Cambridge, CAMBS

C. Borland

Department of Medicine, Hinchingbrooke Hospital, Huntingdon, CAMBS

F. Bottrill

Department of Anaesthetic Research, Papworth Hospital, Papworth Everard, Cambridge, CAMBS

A. Vuylsteke

Department of Anaesthetic Research, Papworth Hospital, Papworth Everard, Cambridge, CAMBS

D. Gordon

Anglia Ruskin University, East Road, Cambridge, CAMBS

A simple model lung has been designed using a membrane oxygenator circuit comprising two membrane oxygenators primed with one to two litres of equine blood, giving reproducible results over several hours. Normoxia and normocapnia were achieved consistently over the duration of the test with a blood flow of 2.5 l/min, oxygenator ventilation gas flow of 5 l/min air with 0.3 l/min O2 and deoxygenator ventilation gas flow of 5 l/min 5% CO2 in N2 with 0.2 l/min CO 2. The measured PaO2 was 81.3 (SD 3.35 mmHg), PvO2 38.3 (SD 1.38 mmHg), PvCO2 60.6 (SD 1.13 mmHg) and PaCO2 36.1 (SD 0.69 mmHg). MO2 and MCO2 were 116 ml/min and 169 ml/min, respectively. An increasing linear relationship was observed for FiO2 and the corresponding PaO2 and, similarly, with FiCO2 and PvCO2, providing reference ranges for this model. Perfusion (2007) 22, 231—238.

Perfusion, Vol. 22, No. 4, 231-238 (2007)
DOI: 10.1177/0267659107083240
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?