This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Rudolph, J. L Articles by Babikian, V. L Search for Related Content PubMed PubMed Citation Articles by Rudolph, J. L Articles by Babikian, V. L Social Bookmarking                   What's this?

Use of a large bore syringe creates significantly fewer high intensity transient signals (HITS) into a cardiopulmonary bypass system than a small bore syringe

Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, USA, Division of Aging, Brigham and Women’s Hospital, Boston, USA, jrudolph{at}partners.org

Daniel Tilahun

Department of Cardiac Surgery, VA Boston Healthcare System, Boston, USA

Patrick R Treanor

Department of Cardiac Surgery, VA Boston Healthcare System, Boston, USA

Val E Pochay

Department of Neurology, VA Boston Healthcare System, Boston, USA

Meetali A Mahendrakar

Northeastern University, Bouvé College of Health Sciences, Boston, USA

Praveen Sagar

Northeastern University, Bouvé College of Health Sciences, Boston, USA

Viken L Babikian

Department of Cardiac Surgery, VA Boston Healthcare System, Boston, USA, Department of Neurology, Boston University School of Medicine, Boston, USA

Introduction: High intensity transient signals (HITS) have been reported to occur following perfusionist intervention during cardiac surgery. This study investigates the relationship of the syringe bore, injection rate, and HITS created.

Methods: Syringes (10 mL) with a male luer-lock connection (Large Bore) and Abboject ‘jet syringes’ with a 20 GA needle and male luer-lock connector (Small Bore) were filled with 10 mL of 0.9 N saline. A perfusionist was randomly assigned a set of four similar syringes followed by the other syringe bore. Each of the four syringes was injected into an in vitro saline-primed cardiopulmonary bypass (CPB) system over 5, 10, 15, or 20 sec. Sixteen randomizations of small and large bore syringes were completed at the four injection times (128 injections). HITS in the CPB arterial line were detected with transcranial Doppler (TCD) probes, were recorded for the 2 min following the injection, and were counted independently off-line by two reviewers.

Results: The use of a large bore syringe compared to a small bore syringe created significantly fewer HITS (29±6 versus 145±17 [mean±SEM], p <0.001) introduced into the CPB arterial line. Injection over a longer time produced significantly fewer HITS than shorter injection times (p <0.001).

Conclusion: Significantly fewer HITS are introduced into the CPB system by using standard syringes and slower injection time.

Perfusion, Vol. 21, No. 1, 67-71 (2006)
DOI: 10.1191/0267659106pf843oa


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R. Dittrich and E. B. Ringelstein Occurrence and Clinical Impact of Microembolic Signals During or After Cardiosurgical Procedures Stroke, February 1, 2008; 39(2): 503 - 511. [Abstract] [Full Text] [PDF]

				J. Lynch and J. Riley Microemboli detection on extracorporeal bypass circuitsa Perfusion, January 1, 2008; 23(1): 23 - 32. [Abstract] [PDF]