Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Perfusion
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ündar, A.
Right arrow Articles by Fraser, C. D
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ündar, A.
Right arrow Articles by Fraser, C. D, Jr
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Comparison of hollow-fiber membrane oxygenators in terms of pressure drop of the membranes during normothermic and hypothermic cardiopulmonary bypass in neonates

Akif Ündar

Congenital Heart Surgery Service, Texas Children’s Hospital, Houston, USA, Division of Congenital Heart Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, USA, aundar{at}psu.edu

W Richard Owens

Congenital Heart Surgery Service, Texas Children’s Hospital, Houston, USA

Mary Claire McGarry

Congenital Heart Surgery Service, Texas Children’s Hospital, Houston, USA

Deborah L Surprise

Congenital Heart Surgery Service, Texas Children’s Hospital, Houston, USA

Vicki D Kilpack

Congenital Heart Surgery Service, Texas Children’s Hospital, Houston, USA

Maryann W Mueller

Congenital Heart Surgery Service, Texas Children’s Hospital, Houston, USA

E Dean McKenzie

Congenital Heart Surgery Service, Texas Children’s Hospital, Houston, USA, Division of Congenital Heart Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, USA

Charles D Fraser, Jr

Congenital Heart Surgery Service, Texas Children’s Hospital, Houston, USA, Division of Congenital Heart Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, USA

The objective of this study was to investigate the effects of two hollow-fiber membrane oxygenators, the Capiox SX10 and the Lilliput 901, on pressure drop of the membranes during normothermic and hypothermic cardiopulmonary bypass (CPB) in neonates.

Methods: Twenty-six congenital heart surgery patients (n=13 in each group) with a mean weight of 3 kg were included in this study. Pressure drops of the membranes, pre- and post-oxygenator extracorporeal circuit pressures (ECC) were recorded during normothermic CPB, hypothermic CPB (208C) and after rewarming. There were no differences between the groups in mean arterial pressure, pump flow rate, temperature, duration of CPB, cross- clamp time or the severity of the surgical repairs.

Results: Pressure drop of the Capiox SX10 oxygenator was significantly lower during normothermic (329/10 versus 559/16 mmHg, p B/0.001), hypothermic (389/15 versus 729/18 mmHg, p B/0.001) and post-rewarming (429/13 versus 729/21 mmHg, p B/0.001) periods compared to the Lilliput oxygenator. In the Capiox group, the pre-oxygenator ECC pressure was also significantly lower during normothermic CPB (1429/27 versus 1849/43 mmHg, p B/0.01), hypothermic CPB (1629/30 versus 1999/38 mmHg, p B/0.01) and after rewarming periods (1729/32 versus 2129/42 mmHg, p B/0.01). Post-oxygenator pressures in the Capiox group were also lower than in the Lilliput group, but results were not statistically significant.

Conclusions: These results suggest that the Capiox SX10 hollow-fiber membrane oxygenator produced significantly lower membrane pressure drops and pre- and post-oxygenator ECC during normothermic and hypothermic CPB. Thus, blood trauma with the Capiox during extracorporeal circulation may be significantly lower compared to the Lilliput. Further studies, including the level of complements, platelets, neutrophils and cytokines, with these oxygenators are warranted.

Perfusion, Vol. 20, No. 3, 135-138 (2005)
DOI: 10.1191/0267659105pf796oa
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 PerfusionHome page
A. Undar, B. Ji, B. Lukic, C. M Zapanta, A. R Kunselman, J. D Reibson, T. Khalapyan, L. Baer, W. J Weiss, G. Rosenberg, et al.
Comparison of hollow-fiber membrane oxygenators with different perfusion modes during normothermic and hypothermic CPB in a simulated neonatal model
Perfusion, November 1, 2006; 21(6): 381 - 390.
[Abstract] [PDF]