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Leucocyte filtration of residual heart-lung machine blood in children undergoing congenital heart surgery

Department of Anaesthesiology, University Hospital Groningen, Groningen, The Netherlands, a.j.de.vries.{at}anest.azg.nl

Y J Gu

Department of Cardiothoracic Surgery, University Hospital Groningen, Groningen, The Netherlands, Department of Biomedical Engineering, University Hospital Groningen, Groningen, The Netherlands

W van Oeveren

Department of Biomedical Engineering, University Hospital Groningen, Groningen, The Netherlands

Cardiopulmonary bypass (CPB) leads to a generalized inflammatory reaction, resulting in increased postoperative leucocyte counts and decreased pulmonary function. In adults, removal of leucocytes from the residual heart - lung machine blood after CPB improved postoperative oxygenation. In children, however, the clinical effects of leucocyte filtration of the residual heart - lung machine blood are unknown. Therefore, we measured postoperative leucocyte counts and arterial blood oxygenation in children undergoing congenital cardiac surgery in a randomized prospective study. Anaesthesia and CPB were standardized. After CPB, the residual heart-lung machine blood was collected as usual. In a group of 25 children, this blood was filtered with a leucocyte depletion filter before transfusion. A control group of 25 children received this blood unfiltered. We found that the postoperative leucocyte counts were significantly lower in the filter group than in the control group (p=0.02, repeated measurements ANOVA). This difference reached a maximum on the second postoperative day (12.9x10⁹/L filter versus 15.9x10⁹/L control, p=0.02, Student’s t-test). Values for the arterial blood oxygenation on the first postoperative day were not different between the two groups (15.5±1 kPa filter versus 14.6±1.3 kPa control, p=0.57, Student’s t-test). We conclude that leucocyte filtration of the residual heart-lung machine blood reduced systemic leucocyte counts, but did not improve arterial blood oxygenation in children after congenital heart surgery.

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