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Perfusion, Vol. 19, No. 2, 127-131 (2004)
DOI: 10.1191/0267659104pf726oa

Inflammatory response in an immunosuppressed patient with Wegener’s granulomatosis

Saeed Mirsadraee

Yorkshire Heart Centre, Leeds General Infirmary, Leeds, UK, niloogan{at}yahoo.co.uk

Alexander Fraser

Department of Rheumatology, Leeds General Infirmary, Leeds, UK

Michael A Kerr

Department of Clinical Biochemistry and Immunology, Leeds General Infirmary, Leeds, UK

Teifi E James

Department of Ophthalmology, The Calderdale Royal Hospital, Leeds, UK; *Currently at Cardiac Unit, Great Ormond Street Hospital, London, UK

Carin van Doorn

Yorkshire Heart Centre, Leeds General Infirmary, Leeds, UK

Background: The use of cardiopulmonary bypass (CPB) triggers a systemic inflammatory response (IR), but it is not known if a similar response occurs in an immuno-suppressed patient with autoimmune disease.

Methods and results: Observational study in a 56-year-old man receiving immunosuppressive therapy for Wegener’s granulomatosis (WG) who underwent aortic valve replacement on CPB. The following markers for IR were studied in the perioperative period: C3a, C5a, neutrophil elastase (NE), interleukin eight (IL-8), white cell count (WCC) and C-reactive protein (CRP). Results were compared with published literature on the IR in patients undergoing coronary revascularisation with and without the use of CPB. All inflammatory markers increased in the perioperative period. The intensity of IR was markedly reduced compared to published literature for patients undergoing coronary revascularisation on CPB and the temporal patients and extend resembled that for off-pump.

Conclusion: In a patient with WG on immunosuppressive therapy the CPB-related IR is reduced.


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