Perfusion

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sheppard, S V
Right arrow Articles by Smith, D C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sheppard, S V
Right arrow Articles by Smith, D C
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Perfusion, Vol. 19, No. 1, 7-10 (2004)
DOI: 10.1191/0267659104pf703oa

Does the use of leucocyte depletion during cardiopulmonary bypass affect exhaled nitric oxide production?

S V Sheppard

Cardiothoracic Centre, Southampton University Hospitals Trust, Southampton, Hampshire, UK, stuart.sheppard{at}suht.swest.nhs.uk

R V Gibbs

Institute of Biomolecular and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, UK

D C Smith

Department of Anaesthesia, Southampton University Hospitals Trust, Southampton, Hampshire, UK

Fifty patients undergoing elective coronary revascularisation were prospectively randomised to receive either a leucocyte-depleting or a control filter inserted into the arterial line of the cardiopulmonary bypass (CPB) circuit. The concentration of exhaled nitric oxide (NO) was measured 15 min before and 30 min after CPB using a real-time chemiluminescence analyser (Logan Research, Northampton, UK). The baseline rate of exhaled NO production was 2.14±0.83 ppb/s in the control group, and 2.58±0.53 ppb/s in leucocyte-depleted group (p = 0.17). Following CPB, the mean rate of exhaled NO production in the control group had increased by 1.51±0.45 ppb/s to 3.65±0.81 ppb/s and in the leucocyte-depletion group had increased by 1.05±0.45 ppb/s to 3.64±0.62 ppb/s. The increase in exhaled NO production was significantly lower in the leucocyte depleted group (p = 0.002), indicating that leucocyte depletion suppressed the increase in exhaled NO production seen following CPB.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
O. Warren, C. Alexiou, R. Massey, D. Leff, S. Purkayastha, J. Kinross, A. Darzi, and T. Athanasiou
The effects of various leukocyte filtration strategies in cardiac surgery
Eur. J. Cardiothorac. Surg., April 1, 2007; 31(4): 665 - 676.
[Abstract] [Full Text] [PDF]