Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Perfusion
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Draaisma, A. M
Right arrow Articles by Hazekamp, M. G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Draaisma, A. M
Right arrow Articles by Hazekamp, M. G
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Increasing the antioxidative capacity of neonatal cardiopulmonary bypass prime solution: anin vitro study

Anjo M Draaisma

Department of Extracorporeal Circulation, Leiden University Medical Centre (LUMC), Leiden, The Netherlands, A.M.Draaisma{at}lumc.nl

Jacek S Molicki

Department of Pediatrics, Division of Neonatology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Nicole Verbeet

Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Rendel Munneke

Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Hans A Huysmans

Department of Cardiothoracic Surgery, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Howard M Berger

Department of Pediatrics, Division of Neonatology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Mark G Hazekamp

Department of Cardiothoracic Surgery, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Inflammation and oxidative damage are believed to play an important role in the postoperative complications after cardiopulmonary bypass (CPB) in neonates. During the preparation of the prime, red blood cells (RBCs) release non-protein-bound iron (NPBI) and free haemoglobin/haem (Hb/haem). The presence of these prooxidants in the prime solution may increase oxidative stress in neonates undergoing CPB. The solution used as the basis of the prime solution may influence the degree of this oxidative stress. We investigated the NPBI and the Hb/haem binding capacities of two different prime solutions: a prime based on pasteurized human albumin and a prime based on fresh frozen plasma. The presence of NPBI and free Hb/haem were measured during and after the preparation of the prime solution. Only in the albumin prime was NPBI detectable. However, in both primes, the concentrations of free Hb/haem increased. Thus, to reduce the prooxidative effects of NPBI and free Hb/haem, RBCs should be added to the prime at the last possible moment. Adding fresh frozen plasma should be considered, as this would result in no detectable NPBI in the prime solution.

Perfusion, Vol. 18, No. 6, 357-362 (2003)
DOI: 10.1191/0267659103pf693oa
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?