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Perfusion
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Cardiopulmonary bypass is not associated with increased jugular venous blood free radical activity

P C Ip-Yam

University Department of Anaesthesia, Royal Liverpool University Hospital, Liverpool UK

P G Browning

The Cardiothoracic Centre, NHS Trust, Liverpool, Liverpool UK

S Behl

The Cardiothoracic Centre, NHS Trust, Liverpool, Liverpool UK

We have measured jugular venous oxygen saturation (sjvO 2) and lactate, arterial and jugular venous blood levels of lipid peroxidation products - malondialdehyde (MDA) and diene conjugates as an index of free radical activity in eight adults undergoing coronary artery bypass surgery. Measurements were carried out at six specific times: T1 - bypass (CPB), T2 - within 5 min before cardiopulmonary within the first minute after the commencement of CPB, T3 - during stable temperature (28°C) on CPB, T4 - during rewarming at 34°C, T5 min after CPB and T6 - at skin closure. There were no significant changes in arterial, jugular venous and arterio-jugular venous (a-jv) differences in diene conjugates and MDA. There was no correlation between sjvO 2, lactate and a-jv differences in MDA and diene conjugates. These results are not indicative of ischaemia-reperfusion injury across the cerebral circulation during hypothermic CPB.

Perfusion, Vol. 18, No. 2, 123-125 (2003)
DOI: 10.1191/0267659103pf650oa
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