This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Özatik, M. A. Articles by Tasdemir, O. Search for Related Content PubMed PubMed Citation Articles by Özatik, M. A. Articles by Tasdemir, O. Social Bookmarking                         What's this?

Do S100ß protein level increases due to inflammation during cardiopulmonary bypass occur without any neurological deficit?

Cardiovascular Surgery Clinic, Türkiye Yüksek htisas Hospital, Ankara, Turkey

Onurcan Tarcan

Cardiovascular Surgery Clinic, Türkiye Yüksek htisas Hospital, Ankara, Turkey

Arzum Kale

Cardiovascular Surgery Clinic, Türkiye Yüksek htisas Hospital, Ankara, Turkey

Göktan Akõn

Cardiovascular Surgery Clinic, Türkiye Yüksek htisas Hospital, Ankara, Turkey

Mustafa Balcõ

Biochemistry Department, Türkiye Yüksek htisas Hospital, Ankara, Turkey

Akif Ündar

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA

Deniz Süha Küçükaksu

Cardiovascular Surgery Clinic, Türkiye Yüksek htisas Hospital, Ankara, Turkey

Erol ener

Cardiovascular Surgery Clinic, Türkiye Yüksek htisas Hospital, Ankara, Turkey

Ouz Tademir

Cardiovascular Surgery Clinic, Türkiye Yüksek htisas Hospital, Ankara, Turkey

Purpose: S100ß protein level correlates with the duration of cardiopulmonary bypass (CPB) and aortic crossclamp times, but is different during pulsatile and nonpulsatile CPB. In this study, we investigated the time course of the release of S100ß protein during and after pulsatile and nonpulsatile CPB.

Patients and methods: This is a prospective study. Twenty patients had open-heart surgery with pulsatile flow and 20 with nonpulsatile flow. We compared complement proteins, interleukins, white blood cells and S100ß protein before the initiation of CPB, immediately prior to aortic crossclamping, following unclamping, and at postoperative 1st and 24th hours.

Results: In the pulsatile CPB group following aortic unclamping, S100ß protein (p= 0.028) and C3a (p= 0.011) levels were significantly lower than those of the nonpulsatile group. In the pulsatile CPB group at postoperative first hour, C3a level (p= 0.018) and absolute neutrophil count (p= 0.034) were significantly lower than those of the nonpulsatile group. None of the patients developed a neurological deficit and all of the patients survived after the operation and were discharged from the hospital.

Conclusion: During CPB, serum S100ß protein level increases and this increase is higher in the nonpulsatile group. High serum level of S100ß protein is associated with increased levels of serum inflammatory mediators and systemic inflammatory response.

Perfusion, Vol. 17, No. 5, 335-338 (2002)
DOI: 10.1191/0267659102pf597oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. Durgut, K. Hosgor, N. Gormus, U. Ozergin, and H. Solak The cerebroprotective effects of pentoxifylline and aprotinin during cardiopulmonary bypass in dogs Perfusion, March 1, 2004; 19(2): 101 - 106. [Abstract] [PDF]