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Perfusion
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In vitro performance characteristics of a high-flux hemodialyzer with a novel polyester-polymer-alloy (PEPA) membrane

M D Smith

Institute of Cell and Protein Engineering, Hannover, Germany

A Mahiout

Institute of Cell and Protein Engineering, Hannover, Germany, mahiou{at}hannover.sgh-net.de

Despite improvements in hemodialyzers with respect to their clearance of middle and high molecular mass molecules, accumulation of specific solutes in the circulation of dialysis patients continues to be a medical problem. A new membrane material, polyester-polymer alloy (PEPA) which has been developed to have a filtration profile akin to that of the natural kidney, is now being used in hemodialyzers. This study evaluates the performance of a PEPA-based hemodialyzer alongside a selection of available competing high-flux dialyzers using official standardized methods. The new membrane material appears to be a viable alternative which offers performance at least as good as that of the competition. The promising results obtained with the PEPA membrane suggest that a detailed clinical performance study should be undertaken.

Perfusion, Vol. 17, No. 2 suppl, 41-45 (2002)
DOI: 10.1191/0267659102pf554oa
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