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Perfusion
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Circuit and protocol for hypoxic hyperthermic isolated limb perfusion to treat malignant melanoma

Leanne M Innet

Department of Cardiothoracic Surgery - Perfusion, Waikato Hospital, Hamilton, innetl{at}hwl.co.nz

Vellimah Haripershad

Department of Cardiothoracic Surgery - Perfusion, Waikato Hospital, Hamilton

Jon Van Den Berg

Department of Cardiothoracic Surgery - Perfusion, Waikato Hospital, Hamilton

Leonard Cooper

Department of Cardiothoracic Surgery - Perfusion, Waikato Hospital, Hamilton

In the treatment of cancer, isolated limb perfusion (ILP) allows what would be a lethal systemic dose of cytotoxic drugs to be administered directly to a tumour site of an extremity. Unfortunately, ILP is a complex, expensive, time-consuming treatment that requires general anaesthesia, vascular surgery and expertise with extracorporeal circuits that may not be available outside a cardiac centre. By streamlining the traditional ILP protocols and eliminating the oxygenator from the circuit, an equally safe and effective technique of hypoxic hyperthermic isolated limb perfusion has been developed.

Perfusion, Vol. 16, No. 4, 325-330 (2001)
DOI: 10.1177/026765910101600410
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