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Haemolysis due to active venous drainage during cardiopulmonary bypass: comparison of two different techniques

Anaesthesiology and Intensive Care Department, Instituto Clinico Sant’Ambrogio, Milan

Luca Negri

Anaesthesiology and Intensive Care Department, Instituto Clinico Sant’Ambrogio, Milan

Marco Babbini

Anaesthesiology and Intensive Care Department, Instituto Clinico Sant’Ambrogio, Milan

Giorgio Latis

Anaesthesiology and Intensive Care Department, Instituto Clinico Sant’Ambrogio, Milan

Boutros Khlat

Anaesthesiology and Intensive Care Department, Instituto Clinico Sant’Ambrogio, Milan

Giuseppe Tarelli

Cardiac Surgery Department, Instituto Clinico Sant’Ambrogio, Milan

Paolo Panisi

Cardiac Surgery Department, Instituto Clinico Sant’Ambrogio, Milan

Enzo Mazzaro

Cardiac Surgery Department, Instituto Clinico Sant’Ambrogio, Milan

Alessandro Bellisario

Cardiac Surgery Department, Instituto Clinico Sant’Ambrogio, Milan

Bruna Borghetti

Perfusion Department, Instituto Clinico Sant’Ambrogio, Milan

Fernanda Bordignon

Perfusion Department, Instituto Clinico Sant’Ambrogio, Milan

Mario Ferrara

Perfusion Department, Instituto Clinico Sant’Ambrogio, Milan

Helga Pavan

Perfusion Department, Instituto Clinico Sant’Ambrogio, Milan

Massimo Meco

Cardiac Surgery Department, Instituto Clinico Sant’Ambrogio, Milan, mecoma{at}inwind.it

To facilitate mini-access for cardiac surgery, two different methods of active venous drainage are used: vacuum assisted drainage and centrifugal pump aspiration on the venous line. The aim of this study was to compare the haemolysis produced using these two techniques.

From June to December 1999, 50 consecutive patients were operated on using a ministernotomy. All of these patients had valvular surgery for either valve repair or valve replacement (9 MVRepair, 11 MVR, 29 AVR, 1 AVR+MVR). They were randomized into two groups: Group A, 25 patients who underwent surgery where vacuum assisted drainage was used, and Group B, 25 patients where kinetic asssisted venous drainage with centrifugal pump venous aspiration was used. Patient characteristics of both groups were similar for age, gender, body weight, body surface area, height, cardiopulmonary bypass (CPB) time, aortic crossclamp time, priming volume, cardioplegia volume, haemoglobin concentration, haematocrit, serum creatinine, bilirubin, lactate dehydrogenase (LDH), serum glutamic oxaloacetic transaminase (sGOT), serum glutamic pyruvic transaminase (sGPT), aptoglobin, reticulocytes, and platelet count. We checked all these laboratory parameters preoperatively, at the end of CPB, and 2 and 24 h after operation. We also checked haemoglobinuria at these same time points. We assessed blood loss at 6, 12, and 24 h after the operation and calculated total postoperative bleeding. There was a tendency towards a greater increase in LDH, sGOT and sGPT in Group A more than in Group B, but these data did not reach statistical significance. Platelet count was always lower in Group A and aptoglobin increased in Group A more than in Group B. More patients in Group A had haemoglobinuria.

These findings indicate that haemolysis is increased more in patients treated with vacuum assisted drainage, when compared to the rise in haemolysis in those treated with centrifugal pump venous drainage. Total bleeding is also greater in Group A.

Perfusion, Vol. 16, No. 4, 313-318 (2001)
DOI: 10.1177/026765910101600408


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