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Effect of Carmeda® BioActive Surface coating versus TrilliumTM Biopassive Surface coating of the oxygenator on circulating platelet count drop during cardiopulmonary bypass

David A Palanzo

Lehigh Valley Hospital, Allentown, Pennsylvania, dpalanzo{at}enter.net

Debra L Zarro

Lehigh Valley Hospital, Allentown, Pennsylvania

Norman J Manley

Lehigh Valley Hospital, Allentown, Pennsylvania

Ralph M Montesano

Lehigh Valley Hospital, Allentown, Pennsylvania

Michael Quinn

Lehigh Valley Hospital, Allentown, Pennsylvania

Barbara-Anne Elmore

Lehigh Valley Hospital, Allentown, Pennsylvania

Patricia A Gustafson

Lehigh Valley Hospital, Allentown, Pennsylvania

Joseph M Castagna

Lehigh Valley Hospital, Allentown, Pennsylvania

An investigation was conducted to evaluate the effect that surface coating of the hollow-fiber membrane oxygenator had on circulating platelet count drop during cardiopulmonary bypass (CPB). Sixty patients undergoing non-emergency myocardial revascularization for coronary artery disease were randomly divided into two groups. Group one (n = 32) received the Carmeda®-coated Maxima-Plus PRF oxygenator while the patients in Group two (n = 28) received the TrilliumTM-coated Affinity oxygenator during CPB. The net platelet count drops for the pump specimen (15-20 min after the initiation of bypass) for the Carmeda and the Trillium groups were 3.6±15.8% and 6.2±10.2%, respectively. The net platelet count drop for the warming specimen for the Carmeda and the Trillium groups were 2.9±19.4% and 0.5±11.0%, respectively. There were no statistically significant differences between the groups. The authors conclude that using either the Carmeda®-coated Maxima-Plus PRF oxygenator or the TrilliumTM-coated Affinity® oxygenator afford similar benefits in regards to preserving circulating platelet counts during bypass.

Perfusion, Vol. 16, No. 4, 279-283 (2001)
DOI: 10.1177/026765910101600403
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