|
Sign In to gain access to subscriptions and/or personal tools.
|
Hypoxia, reoxygenation and the role of systemic leukodepletion in pediatric heart surgery
Bradley S Allen
The Division of Cardiovascular Surgery, The Heart Institute for Children, Hope Children’s Hospital, Oak Lawn, Illinois
Michael N Ilbawi
The Division of Cardiovascular Surgery, The Heart Institute for Children, Hope Children’s Hospital, Oak Lawn, Illinois
As cardiopulmonary bypass (CPB) in infants and neonates is becoming more frequent, the technical performance of these operations for congenital heart disease has made significant progress. However, little research has been carried out into the conduct of CBP in producing myocardial and pulmonary dysfunction. Postoperative organ dysfunction is a problem, particularly for cyanotic infants. This paper examines the experimental and clinical experience of injury brought about by abrupt reoxygenation of the hypoxic, or cyanotic, heart. The modalities of gradual reoxygenation and leukodepletion in limiting this injury are examined, leading to the conclusion that injury can be reduced and possibly ameliorated by changes in intraoperative management during CBP in children with cyanotic disease.
Perfusion, Vol. 16, No. 1 suppl,
19-29 (2001)
DOI: 10.1177/026765910101600i104
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Goritz, H. Schelkle, J.-G. Rein, and S. Urbanek
Dynamic bubble trap can replace an arterial filter during cardiopulmonary bypass surgery
Perfusion,
November 1, 2006;
21(6):
367 - 371.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Barak and Y. Katz
Microbubbles: Pathophysiology and Clinical Implications
Chest,
October 1, 2005;
128(4):
2918 - 2932.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kurusz and B. D Butler
Bubbles and bypass: an update
Perfusion,
January 1, 2004;
19(1_suppl):
S49 - S55.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. S. Allen, J. S. Veluz, G. D. Buckberg, E. Aeberhard, and L. J. Ignarro
Deep hypothermic circulatory arrest and global reperfusion injury: Avoidance by making a pump prime reperfusate--A new concept
J. Thorac. Cardiovasc. Surg.,
March 1, 2003;
125(3):
625 - 632.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Merkle, W. Bottcher, and R. Hetzer
Prebypass filtration of cardiopulmonary bypass circuits: an outdated technique?
Perfusion,
January 1, 2003;
18(1_suppl):
81 - 88.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Urbanek and H.-J. Tiedtke
Improved methods for measurement of gaseous microbubbles during extracorporeal circulation
Perfusion,
December 1, 2002;
17(6):
429 - 434.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. S. Allen
The reoxygenation injury: Is it clinically important?
J. Thorac. Cardiovasc. Surg.,
July 1, 2002;
124(1):
16 - 19.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. S Allen
The role of leukodepletion in limiting ischemia/reperfusion damage in the heart, lung and lower extremity
Perfusion,
March 1, 2002;
17(2_suppl):
11 - 22.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. A Ortolano, G. S Aldea, K. Lilly, P. O'Gara, J. D Alkon, F. Madera, T. Murad, C. P Altenbern, C. S Tritt, A. Capetandes, et al.
A review of leukofiltration in cardiac surgery: the time course of reperfusion injury may facilitate study design of anti-inflammatory effects
Perfusion,
March 1, 2002;
17(2_suppl):
53 - 62.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S J Morris
Leukocyte reduction in cardiovascular surgery
Perfusion,
September 1, 2001;
16(5):
371 - 380.
[PDF]
|
|
|
|
|
