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Use of danaparoid sodium (Orgaran®) as an alternative to heparin sodium during cardiopulmonary bypass: a clinical evaluation of six cases

Philip Fernandes

Clinical Perfusion Services, London Health Sciences Centre, London, Ontario, philip.fernandes{at}lhsc.on.ca

Richard Mayer

Clinical Perfusion Services, London Health Sciences Centre, London, Ontario

James L MacDonald

Clinical Perfusion Services, London Health Sciences Centre, London, Ontario

Andrew G Cleland

Clinical Perfusion Services, London Health Sciences Centre, London, Ontario

Christine Hay-McKay

Clinical Perfusion Services, London Health Sciences Centre, London, Ontario

Heparin-induced thrombocytopenia (HIT) has become more prevalent in today’s cardiac setting and has resulted in the need for alternative anticoagulant therapies.

Danaparoid sodium, one alternative to heparin, has been used in six cardiopulmonary bypass procedures in this hospital. This clinical experience has resulted in the progressive refinement of a protocol for the ‘safe’ clinical use of danaparoid sodium.

Although there were six positive outcomes with the use of danaparoid sodium, alternatives must be explored in order to find the optimal anticoagulant for the treatment of HIT.

Perfusion, Vol. 15, No. 6, 531-539 (2000)
DOI: 10.1177/026765910001500610
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