This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fernando, R. Articles by Chan, R. Search for Related Content PubMed PubMed Citation Articles by Fernando, R. Articles by Chan, R. Social Bookmarking                   What's this?

Anti-inflammatory pre-treatment and the resultant effects of interleukin-10: adjuncts to multi-therapeutical strategies

North Shore University Hospital, School of Cardiovascular Perfusion/Long Island University-CW Post, Manhasset, New York

Richard Chan

North Shore University Hospital, School of Cardiovascular Perfusion/Long Island University-CW Post, Manhasset, New York

With the advent of off-pump coronary bypass surgery, there is increasing demand for research in attenuating the deleterious effects of cardiopulmonary bypass (CPB). An improved understanding of the systemic inflammatory response syndrome (SIRS) has distinguished which areas of components have the most adverse effects and which are, in fact, anti-inflammatory. This classification of inflammatory components allows strategic treatment for those likely to cause the most clinically significant ‘effect’, suitably termed ‘effectors’. This article will identify current methods in treating ‘effectors’, as well as those components having anti-inflammatory effects.

This article selectively features certain inflammatory components by: (1) grouping them as being ‘mediators’ or ‘effectors’; (2) relating them to interleukin-10 (IL-10) and treatments potentiating anti-inflammatory effects; (3) summarizing their mechanisms of action; (4) recognizing the time periods during bypass exhibiting peak levels; and (5) investigating current treatment methods and identifying their significance to ‘effectors’.

A literature search in MEDLINE was performed, featuring articles of the English-language within the past 5 years.

Because of the characteristic of having interlinked multi-component cascades, it is evident that treating SIRS with a one-dimensional method would be inadequate. This article not only confirms the importance of a multi-factorial therapeutic approach, but also targets the inflammatory components having the highest potential for causing direct tissue damage, known as ‘effectors’. In addition, previous studies have found IL-10 to have ‘regulatory effects’ during periods of excessive pro-inflammatory stimuli. These findings may arouse new ideas in exploring the area of anti-inflammatory cytokines. In fact, future treatments may suggest a new classification featuring ‘mediators’, ‘effectors’, and ‘regulators’.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S J Morris Leukocyte reduction in cardiovascular surgery Perfusion, September 1, 2001; 16(5): 371 - 380. [PDF]