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Perfusion, Vol. 15, No. 5, 441-446 (2000)
DOI: 10.1177/026765910001500506
© 2000 SAGE Publications

Oxygen consumption, carbon dioxide production and lactic acid during normothermic cardiopulmonary bypass

Milo Engoren

Department of Anesthesiology, Saint Vincent Mercy Medical Center, Toledo, Ohi, engoren{at}pol.net

Michael Evans

Department of Cardiac Perfusion, Saint Vincent Mercy Medical Center, Toledo, Ohio

The objective of this study was to measure oxygen consumption, carbondioxide production and lactic acid levels during normothermic cardiopulmonary bypass. A prospective study was undertaken in a tertiary care community hospital, involving 20 adults undergoing cardiopulmonary bypass with prolonged (>65 min) crossclamping of the aorta. O2 consumption, CO2 production, hemoglobin and lactic acid levels were measured 5, 35 and 65 min after crossclamping of the aorta. O2 consumption was 79.7 ± 14.5, 78.8 ± 15.4 and 81.5 ± 14.1 ml/min/m2 at 5, 35 and 65 min after crossclamping the aorta. CO2 production was 61.8 ± 42.9, 60.6 ± 26.3 and 62.2 ± 35.9 ml/min/m2 at the same times. Lactic acid levels were 1.6 ± 0.5 mM/dl at all three times and did not correlate with O2 consumption or CO2 production.

In conclusion, although oxygen consumption was low, there was no evidence of abnormal lactate or anaerobic metabolism to suggest tissue ischemia.


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R P. Alston, N. J Glassford, and A. Torrie
Measurement of systemic carbon dioxide production during cardiopulmonary bypass: a comparison of Fick's principle with oxygentor exhaust output
Perfusion, December 1, 2003; 18(6): 339 - 344.
[Abstract] [PDF]