Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Perfusion
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Svenmarker, S.
Right arrow Articles by Engström, K. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Svenmarker, S.
Right arrow Articles by Engström, K. G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Red blood cell trauma during cardiopulmonary bypass: narrow pore filterability versus free haemoglobin

Staffan Svenmarker

Heart Centre, Department of Surgery and Perioperative Sciences, University Hospital Umeå, Staffan.Svenmarker.us{at}vll.se

Erica Jansson

Heart Centre, Department of Surgery and Perioperative Sciences, University Hospital Umeå

Hans Stenlund

Department of Epidemiology and Public Health, University of Umeå

Karl Gunnar Engström

Heart Centre, Department of Surgery and Perioperative Sciences, University Hospital, Umeå

Ten patients admitted for coronary artery bypass grafting were investigated with respect to the influence of cardiopulmonary bypass (CPB) on red blood cell (RBC) trauma. Blood samples were collected prior to, at the start of, and at 30 and 60 min of CPB. RBC deformability was assessed by filtering re-suspended RBCs through a polycarbonate membrane using a computer-controlled filtrometer. Multiple regression analysis was employed to evaluate RBC flow-curve characteristics denoted by the initial filtration rate (IFR) and clogging slope (CS). Release of free haemoglobin was determined concomitantly. IFR was estimated at 90.39 µl/s and CS at -5.32 µl/s2 prior to CPB. During 60 min of CPB, neither IFR nor CS deviated significantly (p > 0.05) from these reference values. However, release of free haemoglobin increased significantly (p < 0.018) from the start of CPB to the 60-min determination. In conclusion, 60 min of CPB seems not to alter significantly RBC deformability in a 5 µm pore filtration model, despite a significant release of haemoglobin.

Perfusion, Vol. 15, No. 1, 33-40 (2000)
DOI: 10.1177/026765910001500106
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
A. M. Morariu, Y. J. Gu, R. C.G. G. Huet, W. A. Siemons, G. Rakhorst, and W. v. Oeveren
Red blood cell aggregation during cardiopulmonary bypass: a pathogenic cofactor in endothelial cell activation?
Eur. J. Cardiothorac. Surg., November 1, 2004; 26(5): 939 - 946.
[Abstract] [Full Text] [PDF]