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Comparison of Sarns 3M heparin bonded to Duraflo II and control circuits in a porcine model: macro- and microanalysis of thrombi accumulation in circuit arterial filters

Department of Surgery and Circulatory Science Graduate Perfusion Program, Department of Surgery, University Heart Center, University of Arizona, Tucson, Arizona

David Arzouman

Department of Surgery and Circulatory Science Graduate Perfusion Program, Department of Surgery, University Heart Center, University of Arizona, Tucson, Arizona

Leigh Kleinert

Department of Surgery and Circulatory Science Graduate Perfusion Program, Department of Surgery, University Heart Center, University of Arizona, Tucson, Arizona

Vangie Patula

Department of Surgery and Circulatory Science Graduate Perfusion Program, Department of Surgery, University Heart Center, University of Arizona, Tucson, Arizona

Stuart Williams

Department of Surgery and Circulatory Science Graduate Perfusion Program, Department of Surgery, University Heart Center, University of Arizona, Tucson, Arizona

Heparin-bonded perfusion circuits have been reported to reduce the thrombus formation during various levels of systemic heparinization. The goal of this study was to compare the efficacy of thrombo-resistance of the Sarns 3M heparin-bonded circuit to Baxter Duraflo II and untreated control in a porcine model. Fifteen Yorkshire pigs (60-65 kg) were anesthetized, heparinized with 3000 IU, intravenously (i.v.) and surgically cannulated with an internal jugular outflow and a femoral vein inflow. All circuits consisted of a 22-Fr venous cannula, centrifugal pump, arterial filter, an 18-Fr cannula for return and connected with equal lengths of 3/8'' polyvinyl chloride tubing. The flows were maintained at 2.0 l/min for 4 h. Thrombus formation in filter samples were morphometrically analyzed through macro-densitometry, light microscopy, and scanning electron microscopy (SEM). Our findings revealed that the 3M circuit had significantly less gross thrombus (p < 0.001), 66% and 84% less microscopic thrombi and fivefold less SEM-measured aggregates (p = 0.03) compared to the Duraflo II and uncoated groups. This study demonstrated that the 3M heparin-bonded circuit had significantly reduced the formation of micro- and macro-thrombi in the minimally heparinized pig model compared to the Duraflo II and untreated control circuits.

Perfusion, Vol. 15, No. 1, 13-20 (2000)
DOI: 10.1177/026765910001500103


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