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Perfusion
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A literature review of cardiopulmonary bypass models for rats

Philippe KEW Ballaux

Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine, London, Philippe.Ballaux{at}uz.kuleuven.ac.be

Terence Gourlay

Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine, London

Chandi P Ratnatunga

Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine, London

Kenneth M Taylor

Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine, London

Cardiopulmonary bypass (CPB) has improved a great deal since its first applications in the early 1950s. If improvements are to be continued, a preclinical model of CPB for small animals is desirable, mainly because of convenience of equipment and low costs. We review the different models of CPB for rats that have been designed, discuss their characteristics and points where improvements may be made. We give suggestions and requirements for a new up-to-date model that could be a useful tool in continued research on the pathophysiology and therapeutic strategies of CPB.

Perfusion, Vol. 14, No. 6, 411-417 (1999)
DOI: 10.1177/026765919901400603
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