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Effect of surface coating on platelet count drop during cardiopulmonary bypass
David A Palanzo
Lehigh Valley Hospital, Allentown, Pennsylvania, David.Palanzo{at}LVH.com
Debra L Zarro
Lehigh Valley Hospital, Allentown, Pennsylvania
Norman J Manley
Lehigh Valley Hospital, Allentown, Pennsylvania
Ralph M Montesano
Lehigh Valley Hospital, Allentown, Pennsylvania
Michael Quinn
Lehigh Valley Hospital, Allentown, Pennsylvania
Patricia A Gustafson
Lehigh Valley Hospital, Allentown, Pennsylvania
This study was designed to investigate the effect of surface coating on platelet count drop during cardiopulmonary bypass (CPB). Sixty patients undergoing open-heart surgery were randomly divided into three groups each receiving a different type of coated hollow-fiber membrane oxygenator. The patients were given either an uncoated oxygenator (noncoated group), an oxygenator coated with Carmeda® (Carmeda group) or an uncoated oxygenator with albumin in the priming solution (albumin group). Comparisons were made in platelet count pre-CPB, on bypass (15-25 min) and during the warming period. Calculations were used to account for the effect of hemodilution. The albumin group had significantly lower platelet count drops (-4.8 ± 7.1%) than the Carmeda group (11.0 ± 8.3%) and the noncoated group (20.3 ± 14.5%). Carmeda surface coating demonstrated some beneficial effects, but to a lesser degree than the albumin.
Perfusion, Vol. 14, No. 3,
195-200 (1999)
DOI: 10.1177/026765919901400307
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