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Molecular advances in cardiac and cardiovascular disease

Annette Basile-Borgia

Department of Cardiovascular Perfusion, Easton Hospital, Easton, Pennsylvania and Department of Molecular Biology, Lehigh University, aeb6{at}lehigh.edu

John H Abel

Department of Molecular Biology, Lehigh University, Bethlehem, Pennsylvania

Haleh Mahloogi

Bethlehem, Pennsylvania

Recent advances in the field of molecular biology have led to a better understanding of the pathological mechanisms of cardiovascular disease. The impact of these findings will shape the future of treatment modalities for cardiovascular disorders. Postulated targets and biological rationale of new techniques are being developed in a race towards molecular therapies for vascular diseases. Whether it is modulation of transmembrane cell receptors or phenotypic changes via vectors that mediate gene transfer, there is no doubt that molecular strategies will be an integral part of the future.

Here we examine past and recent perspectives, describe directions and challenges in cardiac and cardiovascular areas of research, and discuss relevance to the field of cardiovascular perfusion.

Perfusion, Vol. 14, No. 2, 89-99 (1999)
DOI: 10.1177/026765919901400202
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A. E Basile-Borgia and V. C Ware
Life and death of a cardiac myocyte: principles of cellular biology
Perfusion, May 1, 2001; 16(3): 229 - 241.
[Abstract] [PDF]