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Haemocompatibility of paediatric membrane oxygenators with heparin-coated surfaces

Division of Thoracic, Cardiac, and Vascular Surgery, Department of Surgery, Eberhard-Karls-University, Tuebingen, hp.wendel{at}uni-tuebingen.de

Albertus M Scheule

Division of Thoracic, Cardiac, and Vascular Surgery, Department of Surgery, Eberhard-Karls-University, Tuebingen

Friedrich S Eckstein

Division of Thoracic, Cardiac, and Vascular Surgery, Department of Surgery, Eberhard-Karls-University, Tuebingen

Gerhard Ziemer

Division of Thoracic, Cardiac, and Vascular Surgery, Department of Surgery, Eberhard-Karls-University, Tuebingen

Extracorporeal circulation (ECC) in paediatric patients with heparin-coated oxygenation systems is rarely investigated. The objective of this study was to evaluate, preclinically, the haemocompatibility of paediatric membrane oxygenators with heparin-coated surfaces. We compared 16 paediatric membrane oxygenators (Minimax, Medtronic) in an in vitro heart-lung machine model with fresh human blood. Eight of these oxygenation systems had a covalent heparin coating (Carmeda bioactive surface). After 90 min simulated ECC, the heparin-coated systems showed significantly higher platelet count, lower platelet-factor 4 release, reduced contact activation (factor XIIa and kallikrein), and lower neutrophil elastase levels (p < 0.05), compared to the noncoated oxygenator group. More biocompatible materials for paediatric operations may ameliorate the various postperfusion syndromes arising from ECC procedures, particularly unspecific inflammation, hyperfibrinolysis and blood loss.

Perfusion, Vol. 14, No. 1, 21-28 (1999)
DOI: 10.1177/026765919901400104


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