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DOI: 10.1177/026765919801300511 Testing neonate-infant membrane oxygenators with the University of Texas neonatal pulsatile cardiopulmonary bypass system in vitroCardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas and Biomedical Medical Engineering Program, College of Engineering, The University of Texas at Austin, Austin, Texas, undar{at}uthscsa.edu
Biomedical Medical Engineering Program, College of Engineering, The University of Texas at Austin, Austin, Texas and Medical School, The University of Texas Health Science Center at Houston, Houston, Texas
Cardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
Cardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
Cardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
Cardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
Cardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
Cardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas and Biomedical Medical Engineering Program, College of Engineering, The University of Texas at Austin, Austin, Texas
Cardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
Cardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
Cardiothoracic Research Laboratory, Division of Thoracic Surgery, Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Neurologic complications are already well documented after cardiopulmonary bypass (CPB) procedures in neonates and infants. Physiologic pulsatile flow CPB systems may be the alternative to the currently used steady-flow CPB circuits. In addition to the pulsatile pump, a membrane oxygenator should be chosen carefully, because only a few membrane oxygenators are suitable for physiologic pulsatile flow. We have tested four different types of neonate-infant membrane oxygenators for physiologic pulsatility with The University of Texas neonate-infant pulsatile CPB system in vitro. Evaluation criteria were based on mean ejection time, extracorporeal circuit (ECC) pressure, and upstroke of dp/dt. The results suggested that the Capiox 308 hollow-fibre membrane oxygenator produced the best physiologic pulsatile waveform according to the ejection time, ECC pressure, and the upstroke of dp/dt. The Minimax Plus and Masterflo Infant hollow-fibre membrane oxygenators also produced adequate pulsatile flow. Only the Variable Prime Cobe Membrane Lung (VPCML) Plus flat-sheet membrane oxygenator failed to reach the criteria for physiologic pulsatility. Depending on the oxygenator used, the lowest priming volume of the infant CPB circuit was 415 ml and the highest 520 ml.
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