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Perfusion, Vol. 13, No. 5,
304-310 (1998)
DOI: 10.1177/026765919801300504
Modified ultrafiltration in paediatric cardiopulmonary bypass
Wei Wang
Department of Paediatric Cardiothoracic Surgery, Xinhua Hospital, Shanghai Second Medical University, Shanghai
Hui Ming Huang
Department of Paediatric Cardiothoracic Surgery, Xinhua Hospital, Shanghai Second Medical University, Shanghai
De Ming Zhu
Department of Paediatric Cardiothoracic Surgery, Xinhua Hospital, Shanghai Second Medical University, Shanghai
Hong Chen
Department of Paediatric Cardiothoracic Surgery, Xinhua Hospital, Shanghai Second Medical University, Shanghai
Zhao Kang Su
Department of Paediatric Cardiothoracic Surgery, Xinhua Hospital, Shanghai Second Medical University, Shanghai
Wei Xiang Ding
Department of Paediatric Cardiothoracic Surgery, Xinhua Hospital, Shanghai Second Medical University, Shanghai
Cardiopulmonary bypass (CPB), a nonphysiological procedure, is associated with haemodilution and the inflammatory response, causing the accumulation of body water and organ dysfunction. The purpose of this study was to evaluate the efficacy of modified ultrafiltration.
Forty paediatric patients undergoing cardiac operations were randomized into a control group and a modified ultrafiltration group. Blood cells, protein and cytokine concentrations were recorded for 24 h postoperatively.
As the fluid was removed at 50 ml/min, both blood cells and protein were concentrated by modified ultrafiltration (p < 0.001). The tumour necrosis factor (TNF)- concentration was increased and interleukin-8 (IL-8) and endothelin (ET) concentrations were unaltered after ultrafiltration. After correction for albumin, TNF- concentration changed little, and IL-8 and ET concentrations (36.75 ± 12.35, 42.89 ± 15.54) were decreased significantly (21.47 ± 13.87, 26.06 ± 12.54) after ultrafiltration.
Modified ultrafiltration is an effective method for removing excess tissue fluid and concentrating blood after CPB. This technique can also filter out some cytokines.

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