This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Suzuki, I. Articles by Moizumi, Y. Search for Related Content PubMed PubMed Citation Articles by Suzuki, I. Articles by Moizumi, Y. Social Bookmarking                         What's this?

Clinical evaluation of a leucocyte-depleting blood cardioplegia filter (BC1B) for elective open-heart surgery

Department of Clinical Engineering, Sendai Medical Centre, Sendai

Noboru Ogoshi

Department of Clinical Engineering, Sendai Medical Centre, Sendai

Miki Chiba

Department of Clinical Engineering, Sendai Medical Centre, Sendai

Tsunehiro Komatsu

Department of Cardiovascular Surgery, Sendai Medical Centre, Sendai

Yoshimasa Moizumi

Department of Cardiovascular Surgery, Sendai Medical Centre, Sendai

Activation of leucocytes during extracorporeal circulation has attracted attention in recent years as a cause of reperfusion injury in open-heart surgery patients. In the present study, 40 adult patients undergoing elective open-heart surgery were randomized into two groups: 20 using the Pall BC1B leucocyte-depleting filter for blood cardioplegia (group 1) and the other 20 without the filter (group 2). In order to determine if the filter was effective in protecting the myocardium, CPK-MB and troponin-T (TnT) were measured. In addition, efforts were also made to determine appropriate sites at which the BC1B blood cardioplegia filter should be positioned. There were no significant differences between the two groups in terms of conditions of perfusion. No adverse effects were seen in either group. The total leucocyte reduction rate through the filter was 98.1% with the passage of 2 litres of blood through the filter. A pressure drop of 4.4 ± 3.2 mmHg was observed through the filter during use. Statistically significant differences were noted between the two groups in CPK-MB (p = 0.031) and TnT (p = 0.004). Findings obtained in previous studies demonstrate that the various advantages of leucocyte reduction, shown in experimental studies, can be translated into clinical advantages. In conclusion, based on the results in this clinical study showing significant difference in CPK-MB and TnT which are known effective indicators for myocardial injury, between leucoreduced and non-leucoreduced group, the Pall BC1B leucocyte-depleting filter for blood cardioplegia has been shown to be effective in alleviating reperfusion injury in open-heart surgery patients.

Perfusion, Vol. 13, No. 3, 205-210 (1998)
DOI: 10.1177/026765919801300308


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				O. Warren, C. Alexiou, R. Massey, D. Leff, S. Purkayastha, J. Kinross, A. Darzi, and T. Athanasiou The effects of various leukocyte filtration strategies in cardiac surgery Eur. J. Cardiothorac. Surg., April 1, 2007; 31(4): 665 - 676. [Abstract] [Full Text] [PDF]

				R. F. Salamonsen, J. Anderson, M. Anderson, M. Bailey, G. Magrin, and F. Rosenfeldt Total Leukocyte Control for Elective Coronary Bypass Surgery Does Not Improve Short-Term Outcome Ann. Thorac. Surg., June 1, 2005; 79(6): 2032 - 2038. [Abstract] [Full Text] [PDF]

				P. Samankatiwat, I. Samartzis, P. Lertsithichai, D. Stefanou, P. P Punjabi, K. M Taylor, and T. Gourlay Leucocyte depletion in cardiopulmonary bypass: a comparison of four strategies Perfusion, March 1, 2003; 18(2): 95 - 105. [Abstract] [PDF]

				J. Martin, M. Krause, C. Benk, G. Lutter, M. Siegenthaler, and F. Beyersdorf Blood cardioplegia filtration Perfusion, January 1, 2003; 18(1_suppl): 75 - 80. [Abstract] [PDF]

				Poster presentation 2002 Perfusion, January 1, 2003; 18(1_suppl): 89 - 90. [PDF]

				G. A Ortolano, G. S Aldea, K. Lilly, P. O'Gara, J. D Alkon, F. Madera, T. Murad, C. P Altenbern, C. S Tritt, A. Capetandes, et al. A review of leukofiltration in cardiac surgery: the time course of reperfusion injury may facilitate study design of anti-inflammatory effects Perfusion, March 1, 2002; 17(2_suppl): 53 - 62. [Abstract] [PDF]

				G Matheis, M Scholz, A Simon, O. Dzemali, and A Moritz Leukocyte filtration in cardiac surgery: a review Perfusion, September 1, 2001; 16(5): 361 - 370. [Abstract] [PDF]

				S J Morris Leukocyte reduction in cardiovascular surgery Perfusion, September 1, 2001; 16(5): 371 - 380. [PDF]

				G Matheis, M Scholz, A Simon, D Henrich, G Wimmer-Greinecker, and A Moritz Timing of leukocyte filtration during cardiopulmonary bypass Perfusion, January 1, 2001; 16(1_suppl): 31 - 37. [Abstract] [PDF]

				M. B Patel, K. S Kilgore, G. A Ortolano, C. L Gryboski, M. A Qureshi, P. Marcovitz, K. B Naylor, J. L Park, B. Wenz, N. Gikakis, et al. Conditioned blood reperfusion during angioplasty (CoBRA) treatment of acute myocardial infarction Perfusion, January 1, 2001; 16(1_suppl): 39 - 49. [Abstract] [PDF]

				M. Roth, B. Kraus, T. Scheffold, O. Reuthebuch, W. P. Klovekorn, and E. P. Bauer The effect of leukocyte-depleted blood cardioplegia in patients with severe left ventricular dysfunction: A randomized, double-blind study J. Thorac. Cardiovasc. Surg., October 1, 2000; 120(4): 642 - 650. [Abstract] [Full Text] [PDF]

				P G Browning, M Pullan, M Jackson, and A Rashid Leucocyte-depleted cardioplegia does not reduce reperfusion injury in hypothermic coronary artery bypass surgery Perfusion, September 1, 1999; 14(5): 371 - 377. [Abstract] [PDF]