This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Adrian, K. Articles by Wadenvik, H. Search for Related Content PubMed PubMed Citation Articles by Adrian, K. Articles by Wadenvik, H. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?

The effect of albumin priming solution on platelet activation during experimental long-term perfusion

Department of Paediatrics, Division for Paediatric Medicine, Göteborg

Karin Mellgren

Department of Paediatrics, Division for Paediatric Medicine, Göteborg

Maria Skogby

Department of Anaesthesiology, Division for Paediatric Anaesthesiology, Göteborg

Lars Göran Friberg

Department of Paediatrics, Division for Paediatric Surgery, Göteborg

Gösta Mellgren

Department of Paediatrics, Division for Paediatric Surgery, Göteborg

Hans Wadenvik

Department of Medicine, Sahlgrenska University Hospital, Göteborg

The objective of this study was to evaluate the effect of albumin priming on platelet consumption and activation during long-term perfusion. Two identical in vitro extracorporeal membrane oxygenation circuits were used; one was primed with Ringer’s solution containing human serum albumin, the other with Ringer’s solution only. Fresh heparinized human blood was pooled, divided between the two systems and circulated for 24 h at 37°C. Platelet count, plasma concentration of betathromboglobulin (BTG), platelet membrane density of glycoprotein (GP) Ib and of GPIIb/IIIa were assayed before the start and at 0.5, 1, 3, 12 and 24 h of perfusion. In total, seven experiments were performed. We found that during the first hour of perfusion, slightly higher platelet counts (p = 0.058) and lower BTG values (p = 0.0005) were observed in the circuits primed with albumin, compared to the control circuits. No statistically significant differences were observed for the platelet membrane expression of GPIb and GPIIb/IIIa. We conclude that albumin priming appears to transiently prevent platelet consumption and activation during long-term perfusion.

Perfusion, Vol. 13, No. 3, 187-191 (1998)
DOI: 10.1177/026765919801300306


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				L. Simonardottir, B. Torfason, E. Stefansson, and J. Magnusson Changes in muscle compartment pressure after cardiopulmonary bypass Perfusion, May 1, 2006; 21(3): 157 - 163. [Abstract] [PDF]

				R. H. Boks, L. A. van Herwerden, J. J.M. Takkenberg, W. van Oeveren, Y. J. Gu, M. J. Wijers, and A. J.J.C. Bogers Is the use of albumin in colloid prime solution of cardiopulmonary bypass circuit justified? Ann. Thorac. Surg., September 1, 2001; 72(3): 850 - 853. [Abstract] [Full Text] [PDF]

				J. Schaadt Oxygenator thrombosis: an international phenomenon Perfusion, December 1, 1999; 14(6): 425 - 435. [Abstract] [PDF]