Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Perfusion
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by de Vroege, R
Right arrow Articles by Wildevuur, C R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Vroege, R
Right arrow Articles by Wildevuur, C R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biocompatibility of three different membrane oxygenators: effects on complement, neutrophil and monocyte activation

R de Vroege

Department of Cardiac Surgery, University Hospital, Vrije Universiteit Amsterdam, Amsterdam

P MMJ Rutten

Department of Cardiopulmonary Surgery, University Hospital, Vrije Universiteit Amsterdam, Amsterdam

C Kalkman

Department of Anaesthesiology, University Hospital, Vrije Universiteit Amsterdam, Amsterdam

T A Out

Clinical Immunology Laboratory, University Hospital, Vrije Universiteit Amsterdam, Amsterdam

P GM Jansen

Department of Cardiac Surgery, University Hospital, Vrije Universiteit Amsterdam, Amsterdam

L Eijsman

Department of Cardiac Surgery, University Hospital, Vrije Universiteit Amsterdam, Amsterdam

B JM de Mol

Department of Cardiopulmonary Surgery, University Hospital, Vrije Universiteit Amsterdam, Amsterdam

C RH Wildevuur

Department of Cardiac Surgery, University Hospital, Vrije Universiteit Amsterdam, Amsterdam

The inflammatory reaction of extracorporeal circuits can be assessed by measuring complement activation and the release of activation markers of leucocytes. The purpose of this study was to compare three commercially available membrane oxygenators with respect to complement (C3a), granulocyte (lactoferrin) and monocyte (interleukin-6, IL-6) activation. Thirty patients undergoing cardiac surgery were randomly assigned to undergo cardiopulmonary bypass (CPB) with one of the following oxygenators: a polypropylene hollow-fibre membrane (group 1; 2.2 m2), a polypropylene flat-sheet membrane (group 2; 3.1 m2) or a silicone envelope membrane (group 3; 3.5 m2). In all patients, a significant increase in C3a in plasma occurred during CPB with peak levels after the administration of protamine sulphate. In blood samples taken before aortic crossclamp release, at the end of CPB, and 20 min after protamine administration C3a was significantly lower in group 1 than in the other two groups. Lactoferrin increased significantly during CPB in all patients without a significant difference between the groups. IL-6 did not increase during CPB, but raised significantly after 4 h in the intensive care unit in all groups. Moreover, IL-6 was significant lower in group 1 than group 3. The data suggest that the polypropylene hollow-fibre membrane oxygenator, i.e. the oxygenator with the smallest surface area, is more biocompatible than the other types, probably because of a smaller contact surface area.

Perfusion, Vol. 12, No. 6, 369-375 (1997)
DOI: 10.1177/026765919701200605
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 HeartHome page
A. Chukwuemeka
Think "better bypass" before thinking "off-pump"?
Heart, June 15, 2009; 95(12): 955 - 956.
[Full Text] [PDF]

Home page
 PerfusionHome page
K. Charette, Y. Hirata, A. Bograd, L. Mongero, J. Chen, J. Quaegebeur, and R. Mosca
180 ml and less: Cardiopulmonary bypass techniques to minimize hemodilution for neonates and small infants
Perfusion, September 1, 2007; 22(5): 327 - 331.
[Abstract] [PDF]

Home page
 PerfusionHome page
J.W. Mulholland, J.R. Anderson, G.J. Yarham, S. Tuladhur, I. Saed, and M.D. Oliver
Miniature cardiopulmonary bypass the Hammersmith experience
Perfusion, May 1, 2007; 22(3): 161 - 166.
[Abstract] [PDF]

Home page
 Asian Cardiovasc. Thorac. Ann.Home page
S. G Raja and G. D Dreyfus
Modulation of Systemic Inflammatory Response after Cardiac Surgery
Asian Cardiovasc Thorac Ann, December 1, 2005; 13(4): 382 - 395.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
R de Vroege, F te Meerman, L Eijsman, W R Wildevuur, C. R. Wildevuur, and W van Oeveren
Induction and detection of disturbed homeostasis in cardiopulmonary bypass
Perfusion, September 1, 2004; 19(5): 267 - 276.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
P. Massoudy, J. A. Piotrowski, H. C.J.M. van de Wal, R. Giebler, G. Marggraf, J. Peters, and H. G. Jakob
Perfusing and ventilating the patient's lungs during bypass ameliorates the increase in extravascular thermal volume after coronary bypass grafting
Ann. Thorac. Surg., August 1, 2003; 76(2): 516 - 521.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
C. Baufreton, M. Moczar, L. Intrator, P. G. Jansen, H. te Velthuis, P. Le Besnerais, J. P. Farcet, C. R. Wildevuur, and D. Y Loisance
Inflammatory response to cardiopulmonary bypass using two different types of heparin-coated extracorporeal circuits
Perfusion, December 1, 1998; 13(6): 419 - 427.
[Abstract] [PDF]