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Perfusion
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Platelet membrane receptors during short cardiopulmonary bypass - a flow cytometric study

Karel Holada

Institute of Haematology and Blood Transfusion

Jan Simák

Institute for the Care of Mother Child

Vladimir Kucera

Faculty Hospital Motol, Prague

Lenka Roznová

Faculty Hospital Motol, Prague

Tomás Eckschlager

Faculty Hospital Motol, Prague

To elucidate a mechanism of platelet dysfunction during extracorporeal circulation, we performed a study on the surface expression of platelet adhesive receptors (GPlb, GPIIb-IIIa) and activation markers (GMP140, GP53) during short cardiopulmonary bypass (CPB). Ten paediatric patients, age 6-13 years, with atrial or atrioventricular septal defects were studied. The mean CPB time was 52 min (21-110 min). During CPB, a significant drop in platelet count was observed, but not below 130 x 103/µl. The expression of platelet GPlb decreased slightly during CPB and the decrease was not significant. The decrease of GPIIb-IIIa was significant, but only in samples collected either at the end of CPB (89 ± 13%, p < 0.05) or before leaving the operating room (74 ± 14%, p < 0.05). The value of surface expression of platelet activation markers (GMP140, GP53) during CPB was in the range of values for resting platelets. Our results suggest that generalized CPB-induced defects of primary haemostasis are not directly connected to circulation of activated degranulated platelets or to loss of platelet adhesive receptors GPIb-IX and GPIIb-IIIa.

Perfusion, Vol. 11, No. 5, 401-406 (1996)
DOI: 10.1177/026765919601100508
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