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Perfusion, Vol. 11, No. 5, 383-388 (1996)
DOI: 10.1177/026765919601100505

Platelet activation and degradation in an experimental extracorporeal system. A comparison between a silicone membrane and a hollow-fibre oxygenator

K. Mellgren

Department of Paediatric Surgery, Ostra Hospital, University of Göteborg, Göteborg

M. Skogby

Department of Paediatric Surgery, Ostra Hospital, University of Göteborg, Göteborg

Å. Järnås

Department of Paediatric Surgery, Ostra Hospital, University of Göteborg, Göteborg

LG Friberg

Department of Paediatric Surgery, Ostra Hospital, University of Göteborg, Göteborg

H. Wadenvik

Department of Medicine, Sahlgrenska University Hospital, University of Göteborg, Göteborg

G. Mellgren

Department of Paediatric Surgery, Ostra Hospital, University of Göteborg Göteborg

Blood platelets are rapidly activated in contact with biomaterials and, therefore, can be used as markers of the biocompatibility of various components in an extracorporeal system. In the present work, two different oxygenators, one membrane oxygenator (Avecor) and one hollow-fibre oxygenator ('Lilliput', Dideco) were compared. Complete in vitro extracorporeal membrane oxygenation circuits were perfused with fresh, heparinized human blood for 24 h. Eight experiments were performed with the hollow-fibre oxygenator and five experiments with the membrane oxygenator. Blood gases, electrolytes, glucose and haematocrit were kept within physiological limits. Platelet count, plasma concentration of ß-thromboglobulin, platelet serotonin content, platelet membrane glycoprotein Ib and its degradation product glycocalicin, as well as plasma haemoglobin concentration were assayed. As regards most of these variables, significant differences in favour of the hollow- fibre oxygenator were observed.


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