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Troponin T release with warm and cold cardioplegia

ET Brackenbury

Departments of Clinical Biochemistry and Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London

R. Sherwood

Departments of Clinical Biochemistry and Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London

N. Meehan

Departments of Clinical Biochemistry and Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London

MA Whitehorne

Departments of Clinical Biochemistry and Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London

AT Forsyth

Departments of Clinical Biochemistry and Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London

MT Marrinan

Departments of Clinical Biochemistry and Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London

JB Desai

Departments of Clinical Biochemistry and Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London

Cardiac troponin T (cTnT) levels were measured in 41 patients undergoing elective coronary artery surgery. Twenty-one patients received continuous warm antegrade blood cardioplegia to maintain asystole whilst 20 patients received antegrade cold blood cardioplegia intermittently. Serum levels of cTnT were determined preoperatively and at 0, 6, 12 and 18 h postbypass. Peak cTnT levels and total cTnT release (calculated from the area under the curve postoperatively) were found to be significantly higher (p < 0.05: Mann-Whitney) when cold cardioplegic solutions were used.

Continuous warm cardioplegia results in lower cTnT release than intermittent cold blood cardioplegia suggesting that the former may provide better myocardial preservation.

Perfusion, Vol. 11, No. 5, 377-382 (1996)
DOI: 10.1177/026765919601100504
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