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Perfusion
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Lipoproteins in heart disease

Annette Basile-Borgia

Department of Cardiovascular Perfusion, Easton Hospital, Easton, Pennsylvania, Department of Molecular Biology, Lehigh University, Bethlehem, Pennsylvania

John H Abel

Department of Molecular Biology, Lehigh University, Bethlehem, Pennsylvania

Most lipids are carried in the circulation by lipoproteins. Liproproteins and their associated proteins, called apolipoproteins, are currently being studied in an effort to further our understanding of atherosclerotic cardiovascular disease. Lipoprotein assembly, secretion, transportation, modification and clearance are essential elements of healthy lipid metabolism. When one or more of these key steps becomes altered, various disease states are induced. Current data suggest that lipoprotein(a), a low density lipoprotein (LDL)-like particle, is an acute phase reactant that plays a critical role in the modulation of fibrinolysis. Several aspects of lipoproteins and lipoprotein metabolism will be examined. Emphasis will be placed on the proatherogenic and thrombogenic effects of oxidized LDL.

Perfusion, Vol. 11, No. 4, 338-345 (1996)
DOI: 10.1177/026765919601100407
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