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Perfusion, Vol. 11, No. 4, 326-332 (1996)
DOI: 10.1177/026765919601100405

Complement activation during and after open-heart surgery is only marginally affected by the choice of fluid for volume replacement

JL Svennevig

Department of Surgery A, University of Oslo

S. Tølløfsrud

Department of Anaesthesiology, University of Oslo

U. Kongsgaard

Department of Anaesthesiology, University of Oslo

H. Noddeland

Department of Anaesthesiology, University of Oslo

B. Mohr

Department of Anaesthesiology, University of Oslo

M. Øzer

Department of Surgery A, University of Oslo

TE Mollnes

Institute of Immunology and Rheumatology, Rikshospitalet, University of Oslo, Norway

Forty patients undergoing CPB for coronary artery surgery, using a standardized technical setting, were randomized to receive either Ringer's acetate, dextran 70 (Macrodex), polygeline (Haemaccel) or albumin 4% for volume replacement during and after surgery. The choice of fluid did not affect early complement activation (C3 activation products). Higher values of the terminal complement complex (TCC) were found only at the end of the operation in patients receiving polygeline. There were no differences between any two of the four groups during the postoperative course. The use of blood transfusion or autotransfusion and the degree of haemodilution and hypothermia did not affect complement activation.

We conclude that complement activation in association with open-heart surgery is only marginally affected by the choice of fluid for volume replacement.


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