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Perfusion, Vol. 11, No. 2, 103-112 (1996)
DOI: 10.1177/026765919601100204

The acute phase response to cardiopulmonary bypass in children

IM Mitchell

Department of Cardiac Surgery, Royal Hospital for Sick Children

L. Brady

Department of Biochemistry, Royal Hospital for Sick Children

J. Black

Department of Biochemistry, Royal Hospital for Sick Children

Mpg Jamieson

Department of Cardiac Surgery Royal Hospital for Sick Children

Jcs Pollock

Department of Cardiac Surgery Royal Hospital for Sick Children

RW Logan

Department of Biochemistry, Royal Hospital for Sick Children, Glasgow

The endocrine phase of the stress response to cardiopulmonary bypass in children is known to be subtly different from that seen in adults. The aim of this investigation was to determine whether there are similar differences in the acute phase response. Thirteen children were studied (mean age 2.65 years). Each child had congenital heart disease and underwent corrective cardiac surgery. Blood samples taken two days prior to operation and at 6, 9, 12, 24, 48 and 120 hours after were analysed for C-reactive protein, albumin, caeruloplasmin, zinc and copper concentrations. Metal:carrier protein molar ratios were also calculated.

Results demonstrate changes which, although similar to those seen in adults, differed both quantitatively and qualitatively. This is explained by the concept of immaturity leading to a generally poor capacity for protein synthesis and a relative inability to respond to altered circumstances.


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