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Perfusion, Vol. 11, No. 1, 53-56 (1996)
DOI: 10.1177/026765919601100107

The effect of low-dose epsilon-aminocaproic acid on patients following coronary artery bypass surgery

Ralph M Montesano

Lehigh Valley Hospital, Allentown, Pennsylvania

Patricia A Gustafson

Lehigh Valley Hospital, Allentown, Pennsylvania

David A Palanzo

Lehigh Valley Hospital, Allentown, Pennsylvania

Norman J Manley

Lehigh Valley Hospital, Allentown, Pennsylvania

Farrokh S Sadr

Lehigh Valley Hospital, Allentown, Pennsylvania

The effect of low-dose epsilon-aminocaproic acid (EACA) on the postoperative course of 46 patients was studied. Patients undergoing coronary artery bypass grafting were randomly selected in two groups. Group 1 (20 patients) received 5 g EACA upon initiation of cardiopulmonary bypass (CPB). Group 2 (26 patients) received no antifibrinolytic drugs prior to CPB. Neither group received antifibrinolytic drugs after CPB. There was no significant difference between the two groups' blood usage on CPB: 0.65 units in Group 1 and 0.60 units in Group 2. After CPB, blood usage significantly differed: 2.2 ± 1.7 (SD) units in Group 1 and 3.9 ± 3.0 units in Group 2 (p = 0.033). Significant difference was also demonstrated in postoperative blood loss in the first 24 hours: 1610 ± 531 ml in Group 1 versus 2025 ± 804 ml in Group 2 (p = 0.043). Pre-CPB administration of low-dose EACA significantly decreases blood loss and blood usage in the postoperative period.


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