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Perfusion
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Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion

Shu Tao

Department of Paediatric Cardiovascular Surgery, Giannina Gaslini Institute, Children's Hospital, Genoa

G. Calza

Department of Paediatric Cardiovascular Surgery, Giannina Gaslini Institute, Children's Hospital, Genoa

F. Lerzo

Department of Paediatric Cardiovascular Surgery, Giannina Gaslini Institute, Children's Hospital, Genoa

A. Virgone

Department of Paediatric Cardiovascular Surgery, Giannina Gaslini Institute, Children's Hospital, Genoa

N. Camassa

Department of Paediatric Cardiovascular Surgery, Giannina Gaslini Institute, Children's Hospital, Genoa

G. Panizzon

Department of Paediatric Cardiovascular Surgery, Giannina Gaslini Institute, Children's Hospital, Genoa

L. Brunelli

Department of Anaesthesiology, Giannina Gasini Institute, Children's Hospital, Genoa

R. Moretti

Department of Anaesthesiology, Giannina Gasini Institute, Children's Hospital, Genoa

P. Grasso

Department of Anaesthesiology, Giannina Gasini Institute, Children's Hospital, Genoa

GM Ghiggeri

Department of Nephrology Giannina Gaslini Institute, Children's Hospital, Genoa

A. Bertolini

Department of Paediatric Cardiovascular Surgery, Giannina Gaslini Institute, Children's Hospital, Genoa

The glutathione (GSH) system is the main defence of tissues against free radicals and red blood cells (RBC) are the most efficient sites for GSH redox cycle activation.

Total GSH was assayed during cardiopulmonary bypass (CPB) in RBC and serum from the coronary sinus, peripheral arteries and veins in 18 children corrected of their cardiac defect. Our conclusions are: (1) RBC-GSH redox cycle is activated during heart ischaemia and reperfusion; (2) the activation of intracellular GSH system is preponderant compared with the extracellular one; (3) variations in intraerythrocytic total GSH during heart ischaemia and perfusion are detectable in peripheral veins and arteries, which can be the convenient sites for monitoring changes in the GSH cycle; and (4) increased total GSH levels are present in RBC before aortic crossclamping: at the beginning of mechanical ventilation in veins and, when CPB is started, also in arteries.

Perfusion, Vol. 10, No. 1, 45-50 (1995)
DOI: 10.1177/026765919501000108
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