This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Andersen, L. Articles by Rygg, I. Search for Related Content PubMed PubMed Citation Articles by Andersen, L. Articles by Rygg, I. Social Bookmarking                   What's this?

The role of N-acetylcystein administration on the oxidative response of neutrophils during cardiopulmonary bypass

Department of Cardiac Anaesthesia, National University Hospital, Rigshospitalet, Copenhagen

J. Thiis

Department of Cardiac Surgery, National University Hospital, Rigshospitalet, Copenhagen

A. Kharazmi

Department of Clinical Microbiology, National University Hospital, Rigshospitalet, Copenhagen

I. Rygg

Department of Cardiac Surgery, National University Hospital, Rigshospitalet, Copenhagen

The role of N-acetylcystein (NAC) administration on the oxidative response of neutrophils during cardiopulmonary bypass (CPB) was evaluated in a double-blind study. Twenty-four adult patients undergoing coronary artery bypass were included in the study. Twelve patients received NAC as a bolus of 100 mg/kg followed by a continuous infusion of 20 mg/kg/h in the bypass circuit from the beginning to the end of bypass. A further 12 patients received placebo. Citrated blood samples for measurement of oxidative burst response of neutrophils were obtained at different time points during bypass. The oxidative burst response of neutrophils in the patients receiving NAC was significantly low at all times during bypass. Based on these findings NAC appears to act as an oxygen free radical scavenger during open-heart surgery.

Perfusion, Vol. 10, No. 1, 21-26 (1995)
DOI: 10.1177/026765919501000105


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				W. L. Baker, M. W. Anglade, E. L. Baker, C. M. White, J. Kluger, and C. I. Coleman Use of N-acetylcysteine to reduce post-cardiothoracic surgery complications: a meta-analysis Eur. J. Cardiothorac. Surg., March 1, 2009; 35(3): 521 - 527. [Abstract] [Full Text] [PDF]

				B. Ramlawi, H. Otu, S. Mieno, M. Boodhwani, N. R. Sodha, R. T. Clements, C. Bianchi, and F. W. Sellke Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study Ann. Thorac. Surg., October 1, 2007; 84(4): 1166 - 1173. [Abstract] [Full Text] [PDF]

				I. El-Hamamsy, L.-M. Stevens, M. Carrier, M. Pellerin, D. Bouchard, P. Demers, R. Cartier, P. Page, and L. P. Perrault Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: A randomized, double-blind, placebo-controlled clinical trial J. Thorac. Cardiovasc. Surg., January 1, 2007; 133(1): 7 - 12. [Abstract] [Full Text] [PDF]

				U. M. Fischer, A. Antonyan, W. Bloch, and U. Mehlhorn Impact of antioxidative treatment on nuclear factor kappa-B regulation during myocardial ischemia-reperfusion Interactive CardioVascular and Thoracic Surgery, October 1, 2006; 5(5): 531 - 535. [Abstract] [Full Text] [PDF]

				S. G Raja and G. D Dreyfus Modulation of Systemic Inflammatory Response after Cardiac Surgery Asian Cardiovasc Thorac Ann, December 1, 2005; 13(4): 382 - 395. [Abstract] [Full Text] [PDF]

				L. G. Kevin, E. Novalija, and D. F. Stowe Reactive Oxygen Species as Mediators of Cardiac Injury and Protection: The Relevance to Anesthesia Practice Anesth. Analg., November 1, 2005; 101(5): 1275 - 1287. [Abstract] [Full Text] [PDF]

				N. Eren, O. Cakir, A. Oruc, Z. Kaya, and L. Erdinc Effects of N-acetylcysteine on pulmonary function in patients undergoing coronary artery bypass surgery with cardiopulmonary bypass Perfusion, December 1, 2003; 18(6): 345 - 350. [Abstract] [PDF]

				U. M. Fischer, C. S. Cox Jr, S. J. Allen, R. H. Stewart, U. Mehlhorn, and G. A. Laine The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1483 - 1488. [Abstract] [Full Text] [PDF]

				P. Tossios, W. Bloch, A. Huebner, M. R. Raji, F. Dodos, O. Klass, M. Suedkamp, S.-M. Kasper, M. Hellmich, and U. Mehlhorn N-acetylcysteine prevents reactive oxygen species-mediated myocardial stress in patients undergoing cardiac surgery: Results of a randomized, double-blind, placebo-controlled clinical trial J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1513 - 1520. [Abstract] [Full Text] [PDF]

				J. Sochman N-acetylcysteine in acute cardiology: 10 years later: What do we know and what would we like to know?! J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1422 - 1428. [Abstract] [Full Text] [PDF]

				W. Hildebrandt, S. Alexander, P. Bartsch, and W. Droge Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O2 chemosensitivity Blood, March 1, 2002; 99(5): 1552 - 1555. [Abstract] [Full Text] [PDF]

				J. E. REPINE, A. BAST, I. LANKHORST, and The Oxidative Stress Study Gro Oxidative Stress in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., July 1, 1997; 156(2): 341 - 357. [Full Text]